Allogeneic Hematopoietic Cell Transplantation for Advanced Polycythemia Vera and Essential Thrombocythemia
Identifieur interne : 005476 ( Main/Exploration ); précédent : 005475; suivant : 005477Allogeneic Hematopoietic Cell Transplantation for Advanced Polycythemia Vera and Essential Thrombocythemia
Auteurs : Karen K. Ballen [États-Unis] ; Ann E. Woolfrey [États-Unis] ; Xiaochun Zhu [États-Unis] ; Kwang Woo Ahn [États-Unis] ; Baldeep Wirk [États-Unis] ; Mukta Arora [États-Unis] ; Biju George [Inde] ; Bipin N. Savani [États-Unis] ; Brian Bolwell [États-Unis] ; David L. Porter [États-Unis] ; Ed Copelan [États-Unis] ; Gregory Hale [États-Unis] ; Harry C. Schouten [Pays-Bas] ; Ian Lewis [Australie] ; Jean Yves Cahn [France] ; Joerg Halter [Suisse] ; Jorge Cortes [États-Unis] ; Matt E. Kalaycio [États-Unis] ; Joseph Antin [États-Unis] ; Mahmoud D. Aljurf [Arabie saoudite] ; Matthew H. Carabasi [États-Unis] ; Mehdi Hamadani [États-Unis] ; Philip Mccarthy [États-Unis] ; Steven Pavletic [États-Unis] ; Vikas Gupta [Canada] ; H. Joachim Deeg [États-Unis] ; Richard T. Maziarz [États-Unis] ; Mary M. Horowitz [États-Unis] ; Wael Saber [États-Unis]Source :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1083-8791 ] ; 2012.
Abstract
Allogeneic hematopoietic cell transplantation (HCT) is curative for selected patients with advanced essential thrombocythemia (ET) or polycythemia vera (PV). From 1990 to 2007, 75 patients with ET (median age 49 years) and 42 patients with PV (median age 53 years) underwent transplantations at the Fred Hutchinson Cancer Research Center (FHCRC; n = 43) or at other Center for International Blood and Marrow Transplant Research (CIBMTR) centers (n = 74). Thirty-eight percent of the patients had splenomegaly and 28% had a prior splenectomy. Most patients (69%for ET and 67%for PV) received a myeloablative (MA) conditioning regimen. Cumulative incidence of neutrophil engraftment at 28 days was 88% for ET patients and 90% for PV patients. Acute graft-versus- host disease (aGVHD) grades II to IV occurred in 57% and 50% of ET and PV patients, respectively. The 1-year treatment-related mortality (TRM) was 27% for ET and 22% for PV. The 5-year cumulative incidence of relapse was 13% for ET and 30% for PV. Five-year survival/progression-free survival (PFS) was 55%/47%and 71%/48% for ET and PV, respectively. Patients without splenomegaly had faster neutrophil and platelet engraftment, but there were no differences in TRM, survival, or PFS. Presence of myelofibrosis (MF) did not affect engraftment or TRM. Over 45% of the patients who undergo transplantations for ET and PV experience long-term PFS.
Url:
DOI: 10.1016/j.bbmt.2012.03.009
PubMed: 22449610
PubMed Central: 3499973
Affiliations:
- Arabie saoudite, Australie, Canada, France, Inde, Pays-Bas, Suisse, États-Unis
- Australie-Méridionale, Auvergne-Rhône-Alpes, Floride, Maryland, Massachusetts, Minnesota, Ohio, Ontario, Oregon, Pennsylvanie, Rhône-Alpes, Tennessee, Texas, Virginie-Occidentale, Washington (État), Wisconsin, État de New York
- Grenoble, Toronto
- Université de Toronto
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Savani</name><affiliation wicri:level="2"><nlm:aff id="A8">Vanderbilt University Medical Center, Brentwood, Tennessee</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University Medical Center, Brentwood</wicri:cityArea></affiliation></author><author><name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Porter, David L" sort="Porter, David L" uniqKey="Porter D" first="David L." last="Porter">David L. Porter</name><affiliation wicri:level="2"><nlm:aff id="A10">Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Copelan, Ed" sort="Copelan, Ed" uniqKey="Copelan E" first="Ed" last="Copelan">Ed Copelan</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Hale, Gregory" sort="Hale, Gregory" uniqKey="Hale G" first="Gregory" last="Hale">Gregory Hale</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Pediatric Hematology/Oncology/BMT, All Children’s Hospital, St. Petersburg, Florida</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Pediatric Hematology/Oncology/BMT, All Children’s Hospital, St. Petersburg</wicri:cityArea></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation wicri:level="1"><nlm:aff id="A12">Interne Geneeskunde, Academische Ziekenhuis Maastricht, Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Interne Geneeskunde, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Ian" sort="Lewis, Ian" uniqKey="Lewis I" first="Ian" last="Lewis">Ian Lewis</name><affiliation wicri:level="2"><nlm:aff id="A13">Haematology and Bone Marrow Transplant Unit, Royal Adelaïde Hôpital/South Australia Pathology, Adelaïde, South Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Méridionale</region></placeName><wicri:cityArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaïde Hôpital/South Australia Pathology, Adelaïde</wicri:cityArea></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean Yves" last="Cahn">Jean Yves Cahn</name><affiliation wicri:level="3"><nlm:aff id="A14">Département d’Hématologie, Hôpital A. Michallon, CHU de Grenoble, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d’Hématologie, Hôpital A. Michallon, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Halter, Joerg" sort="Halter, Joerg" uniqKey="Halter J" first="Joerg" last="Halter">Joerg Halter</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Internal Medicine, University Hospital Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation wicri:level="2"><nlm:aff id="A16">MD Anderson Cancer Center, University of Texas, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>MD Anderson Cancer Center, University of Texas, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Antin, Joseph" sort="Antin, Joseph" uniqKey="Antin J" first="Joseph" last="Antin">Joseph Antin</name><affiliation wicri:level="2"><nlm:aff id="A17">Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Medical Oncology, Dana Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Carabasi, Matthew H" sort="Carabasi, Matthew H" uniqKey="Carabasi M" first="Matthew H." last="Carabasi">Matthew H. Carabasi</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Hematology/Oncology, West Virginia University Hospitals, Inc., Morgantown, West Virginia</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie-Occidentale</region></placeName><wicri:cityArea>Department of Hematology/Oncology, West Virginia University Hospitals, Inc., Morgantown</wicri:cityArea></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Medicine, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Pavletic, Steven" sort="Pavletic, Steven" uniqKey="Pavletic S" first="Steven" last="Pavletic">Steven Pavletic</name><affiliation wicri:level="2"><nlm:aff id="A22">Graft-vs-Host and Autoimmunity Unit, National Institutes of Health/National Cancer Institute, Bethesda, Maryland</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Graft-vs-Host and Autoimmunity Unit, National Institutes of Health/National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation wicri:level="4"><nlm:aff id="A23">Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Deeg, H Joachim" sort="Deeg, H Joachim" uniqKey="Deeg H" first="H. Joachim" last="Deeg">H. Joachim Deeg</name><affiliation wicri:level="2"><nlm:aff id="A2">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation wicri:level="2"><nlm:aff id="A24">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, Oregon</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22449610</idno><idno type="pmc">3499973</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499973</idno><idno type="RBID">PMC:3499973</idno><idno type="doi">10.1016/j.bbmt.2012.03.009</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002186</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002186</idno><idno type="wicri:Area/Pmc/Curation">002037</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002037</idno><idno type="wicri:Area/Pmc/Checkpoint">002065</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002065</idno><idno type="wicri:Area/Ncbi/Merge">000D54</idno><idno type="wicri:Area/Ncbi/Curation">000D54</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D54</idno><idno type="wicri:doubleKey">1083-8791:2012:Ballen K:allogeneic:hematopoietic:cell</idno><idno type="wicri:Area/Main/Merge">005738</idno><idno type="wicri:Area/Main/Curation">005476</idno><idno type="wicri:Area/Main/Exploration">005476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Allogeneic Hematopoietic Cell Transplantation for Advanced Polycythemia Vera and Essential Thrombocythemia</title><author><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name><affiliation wicri:level="2"><nlm:aff id="A1">Division of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name><affiliation wicri:level="2"><nlm:aff id="A2">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation wicri:level="2"><nlm:aff id="A4">Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Division of Biostatistics, Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation wicri:level="2"><nlm:aff id="A5">Department of Hematology/Oncology, Shands Healthcare, University of Florida, Gainesville, Florida</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Hematology/Oncology, Shands Healthcare, University of Florida, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><affiliation wicri:level="2"><nlm:aff id="A6">Department of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis, Minnesota</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Minnesota</region></placeName><wicri:cityArea>Department of Hematology, Oncology and Transplant, University of Minnesota Medical Center, Minneapolis</wicri:cityArea></affiliation></author><author><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name><affiliation wicri:level="1"><nlm:aff id="A7">Department of Hematology, Christian Medical College Hospital, Vellore, Tamil Nadu, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Hematology, Christian Medical College Hospital, Vellore, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><affiliation wicri:level="2"><nlm:aff id="A8">Vanderbilt University Medical Center, Brentwood, Tennessee</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>Vanderbilt University Medical Center, Brentwood</wicri:cityArea></affiliation></author><author><name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Porter, David L" sort="Porter, David L" uniqKey="Porter D" first="David L." last="Porter">David L. Porter</name><affiliation wicri:level="2"><nlm:aff id="A10">Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Abramson Cancer Center, University of Pennsylvania Medical Center, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Copelan, Ed" sort="Copelan, Ed" uniqKey="Copelan E" first="Ed" last="Copelan">Ed Copelan</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Hale, Gregory" sort="Hale, Gregory" uniqKey="Hale G" first="Gregory" last="Hale">Gregory Hale</name><affiliation wicri:level="2"><nlm:aff id="A11">Department of Pediatric Hematology/Oncology/BMT, All Children’s Hospital, St. Petersburg, Florida</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Pediatric Hematology/Oncology/BMT, All Children’s Hospital, St. Petersburg</wicri:cityArea></affiliation></author><author><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name><affiliation wicri:level="1"><nlm:aff id="A12">Interne Geneeskunde, Academische Ziekenhuis Maastricht, Maastricht, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Interne Geneeskunde, Academische Ziekenhuis Maastricht, Maastricht</wicri:regionArea><wicri:noRegion>Maastricht</wicri:noRegion></affiliation></author><author><name sortKey="Lewis, Ian" sort="Lewis, Ian" uniqKey="Lewis I" first="Ian" last="Lewis">Ian Lewis</name><affiliation wicri:level="2"><nlm:aff id="A13">Haematology and Bone Marrow Transplant Unit, Royal Adelaïde Hôpital/South Australia Pathology, Adelaïde, South Australia</nlm:aff><country>Australie</country><placeName><region type="state">Australie-Méridionale</region></placeName><wicri:cityArea>Haematology and Bone Marrow Transplant Unit, Royal Adelaïde Hôpital/South Australia Pathology, Adelaïde</wicri:cityArea></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean Yves" last="Cahn">Jean Yves Cahn</name><affiliation wicri:level="3"><nlm:aff id="A14">Département d’Hématologie, Hôpital A. Michallon, CHU de Grenoble, Grenoble, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d’Hématologie, Hôpital A. Michallon, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Halter, Joerg" sort="Halter, Joerg" uniqKey="Halter J" first="Joerg" last="Halter">Joerg Halter</name><affiliation wicri:level="1"><nlm:aff id="A15">Department of Internal Medicine, University Hospital Basel, Basel, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Internal Medicine, University Hospital Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><affiliation wicri:level="2"><nlm:aff id="A16">MD Anderson Cancer Center, University of Texas, Houston, Texas</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>MD Anderson Cancer Center, University of Texas, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><affiliation wicri:level="2"><nlm:aff id="A9">Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland, Ohio</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Department of Bone Marrow Transplant, Cleveland Clinic, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Antin, Joseph" sort="Antin, Joseph" uniqKey="Antin J" first="Joseph" last="Antin">Joseph Antin</name><affiliation wicri:level="2"><nlm:aff id="A17">Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Medical Oncology, Dana Farber Cancer Institute, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name><affiliation wicri:level="1"><nlm:aff id="A18">Department of Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Oncology, King Faisal Specialist Hospital and Research Center, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Carabasi, Matthew H" sort="Carabasi, Matthew H" uniqKey="Carabasi M" first="Matthew H." last="Carabasi">Matthew H. Carabasi</name><affiliation wicri:level="2"><nlm:aff id="A19">Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Medical Oncology, Thomas Jefferson University Hospital, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><affiliation wicri:level="2"><nlm:aff id="A20">Department of Hematology/Oncology, West Virginia University Hospitals, Inc., Morgantown, West Virginia</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie-Occidentale</region></placeName><wicri:cityArea>Department of Hematology/Oncology, West Virginia University Hospitals, Inc., Morgantown</wicri:cityArea></affiliation></author><author><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><affiliation wicri:level="2"><nlm:aff id="A21">Department of Medicine, Roswell Park Cancer Institute, Buffalo, New York</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Medicine, Roswell Park Cancer Institute, Buffalo</wicri:cityArea></affiliation></author><author><name sortKey="Pavletic, Steven" sort="Pavletic, Steven" uniqKey="Pavletic S" first="Steven" last="Pavletic">Steven Pavletic</name><affiliation wicri:level="2"><nlm:aff id="A22">Graft-vs-Host and Autoimmunity Unit, National Institutes of Health/National Cancer Institute, Bethesda, Maryland</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Graft-vs-Host and Autoimmunity Unit, National Institutes of Health/National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation wicri:level="4"><nlm:aff id="A23">Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Hospital, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Deeg, H Joachim" sort="Deeg, H Joachim" uniqKey="Deeg H" first="H. Joachim" last="Deeg">H. Joachim Deeg</name><affiliation wicri:level="2"><nlm:aff id="A2">Fred Hutchinson Cancer Research Center, Seattle, Washington</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><affiliation wicri:level="2"><nlm:aff id="A24">Center for Hematologic Malignancies, Oregon Health and Science University, Portland, Oregon</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Oregon</region></placeName><wicri:cityArea>Center for Hematologic Malignancies, Oregon Health and Science University, Portland</wicri:cityArea></affiliation></author><author><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, Wisconsin</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Wisconsin</region></placeName><wicri:cityArea>Department of Medicine, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee</wicri:cityArea></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="ISSN">1083-8791</idno><idno type="eISSN">1523-6536</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Allogeneic hematopoietic cell transplantation (HCT) is curative for selected patients with advanced essential thrombocythemia (ET) or polycythemia vera (PV). From 1990 to 2007, 75 patients with ET (median age 49 years) and 42 patients with PV (median age 53 years) underwent transplantations at the Fred Hutchinson Cancer Research Center (FHCRC; n = 43) or at other Center for International Blood and Marrow Transplant Research (CIBMTR) centers (n = 74). Thirty-eight percent of the patients had splenomegaly and 28% had a prior splenectomy. Most patients (69%for ET and 67%for PV) received a myeloablative (MA) conditioning regimen. Cumulative incidence of neutrophil engraftment at 28 days was 88% for ET patients and 90% for PV patients. Acute graft-versus- host disease (aGVHD) grades II to IV occurred in 57% and 50% of ET and PV patients, respectively. The 1-year treatment-related mortality (TRM) was 27% for ET and 22% for PV. The 5-year cumulative incidence of relapse was 13% for ET and 30% for PV. Five-year survival/progression-free survival (PFS) was 55%/47%and 71%/48% for ET and PV, respectively. Patients without splenomegaly had faster neutrophil and platelet engraftment, but there were no differences in TRM, survival, or PFS. Presence of myelofibrosis (MF) did not affect engraftment or TRM. Over 45% of the patients who undergo transplantations for ET and PV experience long-term PFS.</p></div></front></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Australie</li><li>Canada</li><li>France</li><li>Inde</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country><region><li>Australie-Méridionale</li><li>Auvergne-Rhône-Alpes</li><li>Floride</li><li>Maryland</li><li>Massachusetts</li><li>Minnesota</li><li>Ohio</li><li>Ontario</li><li>Oregon</li><li>Pennsylvanie</li><li>Rhône-Alpes</li><li>Tennessee</li><li>Texas</li><li>Virginie-Occidentale</li><li>Washington (État)</li><li>Wisconsin</li><li>État de New York</li></region><settlement><li>Grenoble</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Ballen, Karen K" sort="Ballen, Karen K" uniqKey="Ballen K" first="Karen K." last="Ballen">Karen K. Ballen</name></region><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><name sortKey="Antin, Joseph" sort="Antin, Joseph" uniqKey="Antin J" first="Joseph" last="Antin">Joseph Antin</name><name sortKey="Arora, Mukta" sort="Arora, Mukta" uniqKey="Arora M" first="Mukta" last="Arora">Mukta Arora</name><name sortKey="Bolwell, Brian" sort="Bolwell, Brian" uniqKey="Bolwell B" first="Brian" last="Bolwell">Brian Bolwell</name><name sortKey="Carabasi, Matthew H" sort="Carabasi, Matthew H" uniqKey="Carabasi M" first="Matthew H." last="Carabasi">Matthew H. Carabasi</name><name sortKey="Copelan, Ed" sort="Copelan, Ed" uniqKey="Copelan E" first="Ed" last="Copelan">Ed Copelan</name><name sortKey="Cortes, Jorge" sort="Cortes, Jorge" uniqKey="Cortes J" first="Jorge" last="Cortes">Jorge Cortes</name><name sortKey="Deeg, H Joachim" sort="Deeg, H Joachim" uniqKey="Deeg H" first="H. Joachim" last="Deeg">H. Joachim Deeg</name><name sortKey="Hale, Gregory" sort="Hale, Gregory" uniqKey="Hale G" first="Gregory" last="Hale">Gregory Hale</name><name sortKey="Hamadani, Mehdi" sort="Hamadani, Mehdi" uniqKey="Hamadani M" first="Mehdi" last="Hamadani">Mehdi Hamadani</name><name sortKey="Horowitz, Mary M" sort="Horowitz, Mary M" uniqKey="Horowitz M" first="Mary M." last="Horowitz">Mary M. Horowitz</name><name sortKey="Kalaycio, Matt E" sort="Kalaycio, Matt E" uniqKey="Kalaycio M" first="Matt E." last="Kalaycio">Matt E. Kalaycio</name><name sortKey="Maziarz, Richard T" sort="Maziarz, Richard T" uniqKey="Maziarz R" first="Richard T." last="Maziarz">Richard T. Maziarz</name><name sortKey="Mccarthy, Philip" sort="Mccarthy, Philip" uniqKey="Mccarthy P" first="Philip" last="Mccarthy">Philip Mccarthy</name><name sortKey="Pavletic, Steven" sort="Pavletic, Steven" uniqKey="Pavletic S" first="Steven" last="Pavletic">Steven Pavletic</name><name sortKey="Porter, David L" sort="Porter, David L" uniqKey="Porter D" first="David L." last="Porter">David L. Porter</name><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><name sortKey="Savani, Bipin N" sort="Savani, Bipin N" uniqKey="Savani B" first="Bipin N." last="Savani">Bipin N. Savani</name><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><name sortKey="Woolfrey, Ann E" sort="Woolfrey, Ann E" uniqKey="Woolfrey A" first="Ann E." last="Woolfrey">Ann E. Woolfrey</name><name sortKey="Zhu, Xiaochun" sort="Zhu, Xiaochun" uniqKey="Zhu X" first="Xiaochun" last="Zhu">Xiaochun Zhu</name></country><country name="Inde"><noRegion><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name></noRegion></country><country name="Pays-Bas"><noRegion><name sortKey="Schouten, Harry C" sort="Schouten, Harry C" uniqKey="Schouten H" first="Harry C." last="Schouten">Harry C. Schouten</name></noRegion></country><country name="Australie"><region name="Australie-Méridionale"><name sortKey="Lewis, Ian" sort="Lewis, Ian" uniqKey="Lewis I" first="Ian" last="Lewis">Ian Lewis</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean Yves" last="Cahn">Jean Yves Cahn</name></region></country><country name="Suisse"><noRegion><name sortKey="Halter, Joerg" sort="Halter, Joerg" uniqKey="Halter J" first="Joerg" last="Halter">Joerg Halter</name></noRegion></country><country name="Arabie saoudite"><noRegion><name sortKey="Aljurf, Mahmoud D" sort="Aljurf, Mahmoud D" uniqKey="Aljurf M" first="Mahmoud D." last="Aljurf">Mahmoud D. Aljurf</name></noRegion></country><country name="Canada"><region name="Ontario"><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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